Circumventing antivector immunity by using adenovirus-infected blood cells for repeated application of adenovirus-vectored vaccines: proof of concept in rhesus macaques

    Journal of virology, Volume 86, Issue 20, 2012, Pages 11031-11042.

    Cited by: 9|Bibtex|Views1|Links
    WOS SCOPUS

    Abstract:

    Adenovirus has been extensively exploited as a vector platform for delivering vaccines. However, preexisting antiadenovirus immunity is the major stumbling block for application of adenovirus-vectored vaccines. In this study, we found that freshly isolated peripheral blood mononuclear cells (PBMCs), mostly CD14(+) cells, from adenovirus s...More

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