Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

Federica Facciotti,Gundimeda S Ramanjaneyulu,Marco Lepore,Sebastiano Sansano,Marco Cavallari,Magdalena Kistowska,Sonja Forss-Petter,Guanghui Ni, Alessia Colone,Amit Singhal,Johannes Berger,Chengfeng Xia,Lucia Mori,Gennaro De Libero

NATURE IMMUNOLOGY（2012）

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摘要

The identity of the self lipids presented by CD1d that select i NKT cells is controversial. De Libero and colleagues identify ether-bonded self lipids generated by the peroxisome enzyme GNPAT can select developing i NKT cells in the thymus.

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nature immunology, science

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