Substituted 2-Aminopyridines As Inhibitors Of Nitric Oxide Synthases
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(2000)
摘要
A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd. All rights reserved.
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