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Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins

Bart L. De Corte,William A. Kinney,Li Liu,Shyamali Ghosh,Livia Brunner,William J. Hoekstra,Rosemary J. Santulli,Robert W. Tuman,Judith Baker,Candace Burns,Jef C. Proost,Brett A. Tounge,Bruce P. Damiano,Bruce E. Maryanoff,Dana L. Johnson,Robert A. Galemmo

Bioorganic & Medicinal Chemistry Letters（2005）

引用 31|浏览15
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摘要
The synthesis and SAR of a new class of piperidine-based αvβ3/αvβ5 integrin antagonists is described.
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关键词
Integrin,β-Aryl propionic acids,Vitronectin
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