Electrophysiological Study In 2 Children With Transient Hypohidrosis Induced By Topiramate

Objective:Hypohidrosis, often associated with hyperthermia, has been reported, mostly in children, as a rare and reversible adverse effect of topiramate, an anticonvulsant drug with a broad spectrum of antiepileptic activity. The aim of our study is to detect a possible skin innervation involvement as the mechanism underlying hypohidrosis in children treated with topiramate.Methods:A neurophysiological study has been performed on 2 children who have developed hypohidrosis tinder topiramate treatment. Electrophysiological data have been recorded during topiramate treatment anti compared with a control group. Sympathetic skin responses have been recorded during topiramate assumption and after its discontinuation.Results:In our 2 cases with hypohidrosis related to topiramatc, electrophysiological study showed normal function of both beta and delta sensory fibers and absent sympathetic skin responses that recovered to normal after topiramate discontinuation.Conclusions:Our findings confirm that topiramate might induce a transitory specific carbonic anhydrase block at the level of sweat glands, without involvement of peripheral nervous system.