Indazole derivatives as novel bradykinin B1 receptor antagonists.

Vera Bodmer-Narkevitch,Neville J Anthony,Victoria Cofre,Samson M Jolly,Kathy L Murphy,Richard W Ransom,Duane R Reiss,Cuyue Tang,Thomayant Prueksaritanont,Douglas J Pettibone,Mark G Bock,Scott D Kuduk

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A new class of indazole-derived bradykinin B1 antagonists and their structure–activity relationships (SAR) is reported. A number of compounds were found to have low-nanomolar affinity for the human B1 receptor and possess acceptable P-gp and pharmacokinetics properties.

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关键词

Bradykinin,Antagonist,Indazole,P-Glycoprotein

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