Synthetic study of fomitellic acids: construction of the AB ring moiety

Makoto Yamaoka,Yuichi Fukatsu,Atsuo Nakazaki,Susumu Kobayashi

Tetrahedron Letters（2009）

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摘要

Stereocontrolled synthesis of a fully functionalized AB ring moiety of fomitellic acids was accomplished. The tricyclic skeleton was stereoselectively constructed by means of titanium(III)-mediated radical cascade cyclization of epoxypolyene. The stereochemistry at C1 and C3 was controlled by a vinylogous Mukaiyama aldol reaction and a Sharpless asymmetric epoxidation, respectively.

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关键词

Titanium(III)-mediated radical cascade cyclization,Epoxypolyene,Vinylogous Mukaiyama aldol reaction,Triterpenoid

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