Concentrations Of Metal Ions In Murine Nickel Allergy And Its Cross-Reactions: Effects Of Lipopolysaccharide
INTERFACE ORAL HEALTH SCIENCE 2009(2010)
摘要
Few adequate animal models for metal allergies have existed so far. However, we found that lipopolysaccharide (LPS) promotes and augments metal allergies in mice and established a murine model close to the actual situations. Here, we investigated the effects of LPS on metal concentrations and on cross-reactions in this murine model. LPS markedly reduced the threshold concentration at both sensitization and elicitation steps in Ni allergy and at its cross-reactions. Our findings suggest that the bacterial milieu is a critically important factor leading to metal allergies.
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关键词
nickel allergy, lipopolysaccharide, hypersensitivity, dermatitis, inflammation
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