Preoperative chemoradiotherapy for carcinoma of the vulva

We report the case of a 71-year-old woman with advanced squamous carcinoma of the vulva who achieved marked tumor regression following therapy with 5-fluorouracil and mitomycin combined with preoperative radiotherapy. The patient underwent radical vulvectomy. On microscopic examination of the lesion, only a minute intradermal focus of apparently viable squamous cell carcinoma with no connection to the overlying epidermis could be seen. This multidisciplinary approach for advanced carcinoma of the vulva is worthy of further exploration in a larger number of patients.