Biosynthesis of salsolinol, a tetrahydroisoquinoline alkaloid, in healthy subjects
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION(1990)
摘要
The R enantiomer of salsolinol was detected in the urine of two out of six healthy subjects, whereas 1,2-dehydrosalsolinol was present in the urine of all the subjects. (S)-salsolinol was never detected. Administration of Madopar for 7 days resulted in the presence of large amounts of (R)- and (S)-salsolinol in the urine of five out of the six subjects, the urinary excretion of 1,2-dehydrosalsolinol being generally not markedly increased.
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关键词
Salsolinol biosynthesis in humans,pyruvic acid,dopamine,1,2-dehydrosalsolinol
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