Phosphorus Amides .10. Rate Acceleration Due To Solvation Effects In The Acid-Catalyzed Cleavage Of Phosphinamides - Application To Acid-Catalysis At Enzymic Active-Sites

Phosphinamides undergo acid-catalyzed reaction with enhanced rates as the amount of water is decreased in acetonitrile from about 20 M to about 1 M. This phenomenon appears to be due to increased activity of acid and increased basicity of substrate as the concentration of water is decreased. The same effects may cause enhanced rates of acid-catalyzed reactions at enzymic active sites.