Optimal synthesis of mesostructured hollow titania nanotubes templated on CaCO3 nanoparticles

Approximate 10µm length of mesostructured hollow titania nanotubes with intact configuration was successfully prepared by using needle-like calcium carbonate and octadecylamine as double templates at room temperature in nonaqueous system. During the whole preparation, two parameters i.e. tetrabutoxytitanium/calcium carbonate molar ratio and annealing temperature, were optimized to obtain titania nanotubes with well-defined tubular morphology and mesoporous structure in tube walls. The as-prepared samples were characterized by scanning electron microscopy, transmission electron microscopy, broad-angle X-ray diffraction, pore size distribution and Brunauer–Emmett–Teller. The results showed that under optimal experimental conditions i.e. tetrabutoxytitanium/calcium carbonate molar ratio (50wt.%) and annealing temperature (773K), the tube materials exhibited uniform tubular structure with a length of 8–15µm and an inner diameter of ∼400nm, a wall thickness of ∼40nm, a surface area of 112.2m2/g and a pore volume of 0.18cm3/g. The optimized titania nanotubes were utilized as a carrier for the immobilized of ibuprofen via a simple adsorption method. It was found that the loaded drug presented good sustained release property in three release media, i.e. simulated body fluid, normal saline and pure water.