High Levels Of Human Factor Ix Transgene Expression In Mice Increase Blood Procoagulant Activity

M. A. Srour,J. Grupp, Th. Albert,J. Oldenburg, H. Fechner,R. Fimmers,R. Schwaab

37TH HEMOPHILIA SYMPOSIUM（2008）

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摘要

Elevated levels of human factor IX (hFIX) in subjects with an objectively con- firmed first episode of deep vein thrombosis (DVT) increase the risk of DVT by a factor of 2 to 3 [3]. A useful marker of increased procoagulant activity, which has already been shown to be associated with DVT and VT as well as other clinical conditions, is the D-dimer [1]

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关键词

Deep Vein Thrombosis, Physiological Saline, Human Factor, Adenoviral Vector, Gene Expression System

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