Immunologic approaches to I i poprotein structure
msra(2010)
摘要
The lipoproteins in plasma represent several sets of discrete particles whose structures are constantly changing because of their interactions in plasma with each other, with any of several enzymes and lipid exchange proteins, and with cell surface receptors. In addition, the entrance into plasma of nascent particles and the removal from plasma of "old" particles gives rise to heterogeneities of structure within the major classes of lipoproteins. Some of these heterogeneities consist of subtle modulations of the conformations of functionally important domains of apo- lipoproteins on the surfaces of lipoproteins. While appro- priate changes of apolipoprotein dispositions accompany "normal" or usual metabolism, abnormal dispositions of apolipoproteins can result from defective protein struc- tures acquired during biosynthesis or post-translational modification. Environmental or disease-induced deviations from usual body metabolism such as modifications of di- etary or hormonal status or changes in physical activity also may give rise to changes in intracellular assembly or in the intravascular catabolism of lipoproteins. These deviations, too, can be expected to produce alterations in lipoprotein structure, which in turn could affect lipopro- tein metabolism. Much of the appreciation of subtle modu- lations of apolipoprotein disposition on the surfaces of lipoproteins and the effect of this on lipoprotein structure and function have come from immunologic studies of lipoproteins and apolipoproteins. First we shall briefly discuss some of the strategies and tactics used in immuno- logic studies and then summarize results obtained for several apolipoproteins.
更多查看译文
关键词
physical activity,enzyme,post translational modification
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络