Procoagulant, Anticoagulant And Fibrinolytic-Activities In Llama Plasma

The haemostatic profile of 46 healthy, adult female Ilamas was evaluated and compared to a human reference plasma. The results indicate that standard laboratory reagents and procedures are suitable for the determination of procoagulant, anticoagulant and fibrinolytic analytes in Ilama plasma. Human recombinant tissue factor is an effective reagent for the prothrombin time assay. With this reagent, Ilama plasma exhibited a clotting time similar to human reference plasma. The activated partial thromboplastin time results were shorter for Ilama plasma than for human plasma, and there was a significant (p<0.05) increase, in the order of tenfold, in factor VIII:C activity when human plasma was used as the reference standard. The activities of other procoagulant proteins, including factor VII, IX, X and XI, were similar irrespective of whether Ilama or human reference standards were used.The anticoagulant or inhibitory activity, as determined by the amounts of alpha(2)-macroglobulin and antithrombin, the fibrinolytic activity, as estimated from the levels of plasminogen and plasminogen activators, as well as fibrinogen values are consistent with those reported for other domestic species such as the horse.