5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists

Scott D. Kuduk,Christina Ng Di Marco,Ronald K. Chang,Michael R. Wood,June J. Kim,Kathy M. Schirripa,Kathy L. Murphy,Richard W. Ransom,Cuyue Tang,Maricel Torrent,Sookhee Ha,Thomayant Prueksaritanont,Douglas J. Pettibone,Mark G. Bock

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

A series of 2,3-diaminopyridine bradykinin B1 antagonists was modified to mitigate the potential for bioactivation. Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with high affinity for the human B1 receptor.

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关键词

Bradykinin B1,Antagonists,Diaminopyridine,Bioactivation

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