A replication-incompetent Rift Valley fever vaccine: Chimeric virus-like particles protect mice and rats against lethal challenge

Robert B. Mandell,Ramesh Koukuntla,Laura J.K. Mogler,Andrea K. Carzoli,Alexander N. Freiberg,Michael R. Holbrook,Brian K. Martin,William R. Staplin,Nicholas N. Vahanian,Charles J. Link,Ramon Flick

Virology（2010）

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摘要

Virus-like particles (VLPs) present viral antigens in a native conformation and are effectively recognized by the immune system and therefore are considered as suitable and safe vaccine candidates against many viral diseases.

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关键词

Rift Valley fever virus,Virus-like particle,Vaccine,Chimeric

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