A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit
Timothy D. Cushing,Vijay Baichwal,Karen Berry,Roland Billedeau,Viola Bordunov,Chris Broka,Mario Cardozo,Peng Cheng,David Clark,Stacie Dalrymple,Michael DeGraffenreid,Adrian Gill,Xiaolin Hao,Ronald C. Hawley,Xiao He,Juan C. Jaen,Sharada S. Labadie,Marc Labelle,Csaba Lehel,Pu-Ping Lu,Joel McIntosh,Shichang Miao,Camran Parast,Youngsook Shin,Eric B. Sjogren,Marie-Louise Smith,Francisco X. Talamas,George Tonn,Keith M. Walker,Nigel P.C. Walker,Holger Wesche,Chris Whitehead,Matt Wright,Michelle F. Browner Bioorganic & Medicinal Chemistry Letters（2011）
摘要
A novel series of thiosemicarbazides was discovered as potent inhibitors of IKKβ.
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关键词
IKKβ,IKKα,Semithiocarbazones,Semicarbazones
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