Libraries Of Angiotensin Converting Enzyme Inhibitors: Solid-Phase Synthesis And Affinity Selection

Christopher Blackburn,Aruna Pingali,Terry Kehoe,Lee W. Herman,Hongqi Wang,Steven A. Kates

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1997）

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摘要

Libraries of ACE inhibitors were prepared by solid-phase methods involving reductive alkylation of resin-bound dipeptides, H-X-Pro-DHPP-PEG-PS or H-X-X-PAL-PEG-PS. Affinity selection of the library components identified hydrophilic N-alkylated dipeptides as potential inhibitors. (C) 1997 Elsevier Science Ltd.

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关键词

angiotensin,enzyme inhibitors,synthesis,solid-phase

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