Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

Bioorganic & Medicinal Chemistry Letters(2004)

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摘要
A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta™) has proven to be effective in clinical trials for the treatment of depression.
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clinical trial
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