Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates

Biochemical Pharmacology, pp. 1843-1849, 2002.

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Keywords:
secys-conjugatesglutathione- s -transferaseselenocysteine se -conjugatesrt-pcrcytochrome p450More(22+)

Abstract:

Several selenocysteine Se -conjugates (SeCys-conjugates) prevent against chemically induced carcinogenesis. Bioactivation to selenols (RSeH) by β-lyases is thought to be critical, but the mechanism of tumor suppression remains unclear. Induction of phase II biotransformation enzymes is a possible mechanism of chemoprevention. In this stud...More

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