Discovery and SAR studies of novel GlyT1 inhibitors
Bioorganic & Medicinal Chemistry Letters（2007）
摘要
A novel series of GlyT1 inhibitors and their structure–activity Relationships (SAR) are described. Members of this series are highly potent and selective transport inhibitors which are shown to elevate glycine levels in cerebrospinal fluid.
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关键词
Glycine transporter,GlyT1,GlyT2,Schizophrenia
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