Catecholamine-synthesizing enzymes in paraganglia of aged Fischer-344 rats
Cell and Tissue Research(1984)
摘要
The catecholamine-synthesizing enzymes, tyrosine hydroxylase, dopamine-ß-hydroxylase and phenylethanolamine-N-methyltransferase were examined by immunohistochemistry in hypertrophied paraganglia of aged male Fischer-344 rats. All paraganglionic cells reacted with antibodies against tyrosine hydroxylase. Dopamine ß-hydroxylase was identified in most paraganglionic cells, indicating that they synthesized norepinephrine. A variable number of paraganglia were positive for phenylethanolamine-N-methyltransferase, which suggested that they synthesized epinephrine. The formaldehyde-induced fluorescence method demonstrated greenish-yellow fluorescence or yellowish-brown fluorescence. The intensity of the fluorescence was in the same range as in adrenal medullary cells. The observations indicate that paraganglia are capable of synthesizing epinephrine.
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关键词
Immunohistochemistry,Paraganglia,Aging,Catecholamines,Catecholamine-synthesizing enzymes
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