Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen
The Journal of infectious diseases, Volume 193, Issue 5, 2006, Pages 625-633.
Four single-chain variable fragments (scFvs) against protective antigen (PA) and 2 scFvs against lethal factor (LF) of anthrax were isolated from a phage display library generated from immunized chimpanzees. Only 2 scFvs recognizing PA (W1 and W2) neutralized the cytotoxicity of lethal toxin in a macrophage lysis assay. Full-length immuno...More
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