A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol.

Danyang Liu,Durk Dijkstra,Jan B de Vries,Håkan V Wikström

Bioorganic & Medicinal Chemistry（2008）

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摘要

1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol is an extremely potent dopamine receptor agonist. As a catecholamine, this compound is comparable to apomorphine for the treatment of Parkinson’s disease.

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关键词

Catecholamine,Enone prodrug,Microdialysis,Parkinson’s disease

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