Synthesis, crystal structure analysis, and pharmacological characterization of desmethoxy-sila-venlafaxine, a derivative of the serotonin/noradrenaline reuptake inhibitor sila-venlafaxine

The syntheses and crystal structure analyses of rac-desmethoxy-sila-venlafaxine (rac-3) and its hydrochloride rac-3·HCl are reported. Compound rac-3 is a derivative of rac-sila-venlafaxine (rac-1b), a sila-analogue of the serotonin/noradrenaline reuptake inhibitor rac-venlafaxine (rac-1a). The pharmacological properties of rac-1a, rac-1b, rac-2, and rac-3 are compared.