Separation of Chlordiazepoxide and Selected Chlordiazepoxide Mixtures Using Capillary SFC

The analysis of chlordiazepoxide and selected chlordiazepoxide mixtures using supercritical fluid chromatography (SFC) has been investigated. The separations were carried out on four different stationary phases (SB-methyl-100, SB-biphenyl-30, SB-smectic and SB-cyanopropyl-50) with carbon dioxide as the mobile phase and flame ionization detection. The relative retention data obtained using the SFC method is compared with HPLC methods.