Knochenmarktransplantation - eine neue Option bei schwerem SLE?

High-dose chemotherapy with subsequent transplantation of hematopoietic stem cells is currently being discussed as a new treatment option in severe cases of SLE and other autoimmune disorders. This review summarizes current theoretic considerations, experimental results, and clinical data. Present knowledge appears to indicate that autologous transplantation of purged peripheral blood progenitor cells is best able to balance long-term remission and an acceptable risk of side effects. Another possible option is allogeneic transplantation of purged peripheral blood progenitor cells.