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Cyanoguanidine-based Lactam Derivatives As a Novel Class of Orally Bioavailable Factor Xa Inhibitors

Yan Shi,Jing Zhang,Mengxiao Shi,Stephen P. O'Connor,Sharon N. Bisaha,Chi Li,Doree Sitkoff,Andrew T. Pudzianowski,Saeho Chong,Herbert E. Klei,Kevin Kish,Joseph Yanchunas,Eddie C. -K. Liu,Karen S. Hartl,Steve M. Seiler,Thomas E. Steinbacher,William A. Schumacher,Karnail S. Atwal,Philip D. Stein

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 22|Views69
Key words
Factor Xa inhibitor,Cyanoguanidine,Bioisostere,Thiourea,Ketene aminal,Bioavailable
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