A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.

A convenient one-pot synthetic route was developed for the preparation of asymmetric 1,3-dialkyl-1,3,5-triazine-2,4,6-triones from isocyanates, primary amines and N-chlorocarbonyl isocyanate. This methodology was applied to the synthesis of a chemical library acting as antagonists of the hGnRH receptor.