Low Level of B-type Natriuretic Peptide in Relation to Poor Prognosis in Patients with Advanced Left Ventricular Systolic Dysfunction

Background. B-type/brain natriuretic peptide (BNP) is released from the cardiac ventricles in response to increased wall tension. Elevated circulating BNP in heart failure (HF) usually indicates. poor outcome and compen- sation. In advanced chronic HF, however, low level of BNP may reflect an impaired neurohormonal response. The primary aim of present study was to investigate the prognostic value of low BNP level in advanced heart failure pa- tients. Materials and Methods. 50 advanced HF patients with New York Heart Association (NYHA) functional class ill and N were enrolled in this study. Their blood BNP level were measured by Biosite Triage BNP test on ad- mission and they were followed-up for 12:t 2 month after hospital discharge. Results. Cardiovascular mortality dur- ing follow-up was 24%. BNP levels were lower in patients who died (501:tn vs. 877 :t 89 ng/L, P更多