Novel Pyrrole-Containing Progesterone Receptor Modulators.

J Wrobel,Ma Collins, V Hudak, R Bender,A Fensome,Pw Zhang,L Miller,R Winneker,Zm Zhang,Y Zhu,Rj Unwalla

Bioorganic & Medicinal Chemistry Letters（2003）

引用 65|浏览10

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摘要

A series of 1,4-dihydro-2H-[d][3,1]-benzoxazin-2-one and 1,3-dihydro-[3H]-indol-2-one containing 6- or 5-, respectively, appended substituted pyrrole moieties were synthesized and evaluated for their ability to modulate the activity of the progesterone receptor (PR).

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关键词

progesterone receptor,structural change

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