Influence Of Liquid Bonding Strength On Power-Consumption During Granulation In A High Shear Mixer

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY(1988)

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摘要
AbstractA comparison between the effects of different binders on power consumption and -granule growth by granulation in a Fielder PMAT 25 high shear mixer demonstrates that the power consumption is influenced by the intra-granular porosity and the surface tension of the binder solution. It is suggested that the effects are due to a correlation between the power consumption and the strength of mobile liquid bondings in the moist agglomerates. It is shown that the power consumption reflects the change of the intragranular porosity for a particular granulation process with dicalcium phosphate.
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bond strength
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