Estrogen biosynthesis in human H295 adrenocortical carcinoma cells

    Molecular and Cellular Endocrinology, pp. 115-120, 2009.

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    human adrenal cortexakr1c3aromatasehuman adrenocortical h295 cellscyp19More(6+)

    Abstract:

    Adrenocortical carcinoma is an uncommon malignancy and feminizing symptoms secondary to adrenal estrogen-secretion are extremely rare. The direct secretion of estradiol by adrenocortical tumors requires, in addition to the expression of aromatase (CYP19), the expression of one or more of the reductive 17beta-hydroxysteroid dehydrogenases....More

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