Heritability Of Surface Area And Cortical Thickness: A Comparison Between The Human Connectome Project And The Uk Biobank Dataset

Heritability of the regional thickness/surface in human cortex is established. Yet the estimates vary substantially depending on cohorts or the information they are derived from: pedigree or genotyping. Here we present three heritability studies of the cortex phenotype in two cohorts showing: i) both pedigree and genotyping or ii) genotyping only. We obtained clearly correlated heritability values between studies with a shift appearing between cohorts. Spatial pattern of heritability remains highly consistent across cohorts