LuxR dependent quorum sensing inhibition by N,N'-disubstituted imidazolium salts.

Mohamad Sabbah,Laurent Soulère,Sylvie Reverchon,Yves Queneau,Alain Doutheau

Bioorganic & Medicinal Chemistry（2011）

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摘要

N,N′-Disubstituted imidazolium salts have been prepared and tested as LuxR dependent quorum sensing inhibitors. Some of them displayed IC50 in the micromolar range. These results suggest that a disubstituted imidazolium ring may be considered as a new pharmacophore for QS inhibition.

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关键词

Quorum sensing,Imidazolium,Antagonist,LuxR,AHL

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