Issues In Translation Of Pharmacogenomics Into Clinical Practice
PHARMACOGENOMIC TESTING IN CURRENT CLINICAL PRACTICE: IMPLEMENTATION IN THE CLINICAL LABORATORY(2011)
摘要
Clinical laboratory tests are commonly used for supporting the diagnosis and prognosis of a disease, monitoring the efficacy
progress of therapeutic management decisions, and measuring the foreign toxins. Recent advances in genomics have resulted
in the generation of new assay panels to support personalized drug therapy – this offers new opportunities for clinical laboratories
to make important contributions to healthcare. Pharmacogenomics (PGx) is a recognized discipline within pharmacology that
involves testing relevant human genes, whose products are involved with the inter-individual variability of a drug’s pharmacokinetics,
pharmacodynamics, and human leukocyte antigen (HLA) system profile. The effective use of PGx testing promises to improve the
therapeutic efficacy of drugs while reducing the incidence and severity of adverse drug effects, and drive the optimum drug
selection for therapy.
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关键词
Pharmacokinetics,Pharmacodynamics,Pharmacogenomics,Barriers,Clinical laboratory improvement act
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