Inhibition of phosphorylase phosphatase by polyamines

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, pp. 1040-1046, 1978.

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Abstract:

Phosphorylase phosphatase from rabbit liver or from bovine heart, purified as the M r 35,000 form, is inhibited by the naturally occurring polyamines, spermine and spermidine. The inhibition is apparently competitive with a K i of 0.037 mM for spermine and 0.65 mM for spermidine. Further investigation showed that the inhibition is substra...More

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