Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Bioorganic & Medicinal Chemistry Letters(2003)
摘要
In our continuing efforts to identify small molecule vitronectin receptor antagonists, we have discovered a series of phenylbutyrate derivatives, exemplified by 16, which have good potency and excellent oral bioavailability (approximately 100% in rats). This new series is derived conceptually from opening of the seven-membered ring of SB-265123.
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