Reduced cell number in the neocortical part of the human fetal brain in Down syndrome
Annals of Anatomy - Anatomischer Anzeiger(2008)
摘要
Mental retardation is seen in all individuals with Down syndrome (DS) and different brain abnormalities are reported. The aim of this study was to investigate if mental retardation at least in part is a result of a lower cell number in the neocortical part of the human fetal forebrain. We therefore compared brains of DS fetuses aged 19 weeks of gestation with normal control brains. The cell numbers were estimated using the optical fractionator method.
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关键词
Development,Fetal zones,Human,Neocortex,Stereology,Trisomy 21
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