N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators

Kevin M. Thewlis,Laura Aldegheri,Mark H. Harries,Claudette Mookherjee,Beatrice Oliosi,Simon E. Ward

Bioorganic & Medicinal Chemistry Letters（2010）

引用 15|浏览36

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摘要

This work describes the synthesis and biological activity of a series of pyrrolidine and tetrahydrofuran analogues as AMPA receptor positive modulators. Ar=substituted phenyl or heterocycle.

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关键词

AMPA,Receptor,Modulators,Synthesis

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