Discovery of novel aminothiadiazole amides as selective EP3 receptor antagonists

Mark A. Hilfiker,Ning Wang,Xiaoping Hou,Zhimin Du,Mark A. Pullen,Melanie Nord,Rakesh Nagilla,Harvey E. Fries,Charlene W. Wu,Anthony C. Sulpizio,Jon-Paul Jaworski,Dwight Morrow,Richard M. Edwards,Jian Jin

Bioorganic & Medicinal Chemistry Letters（2009）

引用 17|浏览37

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摘要

A series of 2-aminothiadiazole amides has been identified with potent EP3 antagonist activity, good rat DMPK properties, and excellent prostenoid receptor selectivity.

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关键词

Prostenoid,EP3,Thiadiazole,7-TM,PGE2,EP receptor,Prostaglandin

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