Thermotropic properties of dipalmitoyl phosphatidyl choline stearylamine liposomes

Fluorescence polarization and differential scanning calorimetry measurements made on dipalmitoyl phosphatidyl choline-stearylamine mixed liposomes show striking changes in the biophysical properties of these vesicles. The liposomes formed have transition temperature largely shifted to higher temperature and evolve to larger structure. These results strongly suggest that the alteration of liposomal structures due to the incorporation of lipid soluble compound like drugs requires physico-chemical studies before any screening with liposomes as pharmacological capsules.