Combination of Pre-Operative Radiotherapy and Surgery Suppresses Local Accumulation of Collagen and TGF-β1 in Rats11This study was supported by grants from the Swedish Medical Society, Dir. A. Påhlsson’s Foundation, Malmö, Swedish Cancer Foundation, Ruth and Richard Julin’s Foundation, Malmö University Hospital Cancer Foundation, Malmö University Hospital, Lundgren’s Foundation, Gunnar Nilsson’s Foundation, Apotekaren Hedberg’s Fond, and from the Danish Medical Research Council (22-02-0287).

Louis B. Johnson,Diya Adawi,Magnus S. Ågren,Lars N. Jorgensen,Lena Wittgren,Sören Mattsson,Peter Blomquist,Finn Gottrup,Bengt Jeppsson

Journal of Surgical Research（2006）

引用 14|浏览3

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摘要

Conclusion A clinically relevant fractionated radiation scheme reduced subcutaneous collagen accumulation pre-operatively and profoundly within the radiation field post-operatively after laparotomy, possibly because of lowered TGF-β1 levels.

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关键词

collagen,radiation injuries,transforming growth factor beta,wound healing

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