Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.

Zhicai Wu,Mark E Fraley,Mark T Bilodeau,Mildred L Kaufman,Edward S Tasber,Adrienne E Balitza,George D Hartman,Kathleen E Coll,Keith Rickert,Jennifer Shipman,Bin Shi,Laura Sepp-Lorenzino,Kenneth A Thomas

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.

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