Platelet-Aggregation And Fatty-Acid Composition Of Platelets In Type-1 Diabetes-Mellitus
CLINICA CHIMICA ACTA(1991)
摘要
A raised content of arachidonic acid in platelets from diabetic patients with retinopathy was found without differences in platelet aggregation: platelet aggregability was not related to platelet fatty acid composition. In diabetes, platelet aggregation was inversely correlated to non-esterified fatty acids in plasma and may suggest an inhibiting effect. Mean platelet volume was raised in the diabetic patients, but without hyperaggregability. The findings do not exclude a relationship between platelet fatty acids and platelet aggregability, but suggest that variations in levels of nonesterified fatty acids in plasma might interfere with platelet aggregation.
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关键词
ARACHIDONIC ACID, DIABETES-MELLITUS, DIABETIC RETINOPATHY, EICOSAPENTAENOIC ACID, NONESTERIFIED FATTY ACID, PLATELET AGGREGATION
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