2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

2-Phenyl-9H-purine-6-carbonitrile derivatives were designed as selective human cathepsin S inhibitors through P2 optimization and transition state stabilization by an intramolecular H-bond.

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关键词

Cathepsin S,Transition state,Purine-6-carbonitrile,Lysosomotropism

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