Translational symphony in (hnRNP) C major for APP

Nature Structural & Molecular Biology（2010）

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摘要

Stringent post-transcriptional regulation of the amyloid precursor protein (APP) is critical for maintaining proper neurological function. In this issue, Lee et al . identify two RNA-binding proteins, FMRP and hnRNP C, that have opposite effects on APP translation via competing interactions, surprisingly, with the mRNA coding region.

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关键词

Gene regulation,Translation,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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