Upregulation of Actin Gene Expression in Cells Expressing Exogenous β-Amyloid Precursor Protein

We investigated the effects of beta-amyloid peptide precursor (APP) overexpression upon the levels of other mRNAs. Using quantitative slot-blot hybridization and immunoblot analysis we observed that enhanced levels of APP elevated the levels of beta-actin and beta-actin mRNA, Our results also suggest that the cytoplasmic domain of APP is crucial for the elevation in beta-actin gene expression. (C) 1997 Academic Press.