1001 INTERIM ANALYSIS FROM TRIC-1 A STUDY OF METFORMIN WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN TREATMENT NAIVE GENOTYPE 1 CHRONIC HEPATITIS C WITH INSULIN RESISTANCE

S375HCV RNA at Week 4 on TVR/P/R (12+12 regimen) Prior P/R virologic responses in Phase 2 studies N <25 IU/mL n (%) 25 IU/mL n (%) Did not meet Stopping rule Met Stopping rule Week 4 NR 17 12 (71) 5 a (29) Week 12 NR 3 2 (67) 1 b (33) Week 24 detectable 7 7 (100) 0 Week 20 breakthrough 1 1 (100) 0 Relapsers 4 4 (100) 0 a 1 with 33, 1 with 43, 3 with >100 IU/mL.b 1 with 28 IU/mL.